Bachelor's degree in life sciences

Objectives To train students in the various analytical techniques for both solutions and solid states, enabling them to experimentally approach the analysis and control of active ingredients alone or in pharmaceutical forms, as well as pharmacokinetics.

• Determine and characterize the crystalline polymorphism of pharmaceutical substances using thermal and diffractoremic methods.
• Analysis and determination of various elements in pharmaceutical substances/blood/urines by atomic spectrophotometry.
• Conceptualization and modeling of Newtonian, non-Newtonian and viscoelastic behavior. Application to viscosimetric and rheological measurements of health products.
• Introduction to separative analytical methods and their coupling with mass spectrometry, applied to the identification and determination of xenobiotics.

Content (CM-TD-TP) The various analytical methods are presented in lectures and illustrated by numerous examples relating to the drug. A few hours of tutorials demonstrate the complementary nature of all these techniques. A large number of practical exercises (32h/student) directly linked to the lectures enable students to familiarize themselves with the different types of equipment and thus gain a better grasp of all these techniques from both a fundamental and technical standpoint. Instructors Montpellier University

• C. PERRIN
• H. VAN DEN BERGEN
• A. EL GHZAOUI

Objectives Pharmacology: Through the pharmacology course, students are expected to acquire a sound knowledge of the drug families covered. The pharmacology course describes the mechanism(s) of action of each drug family, its pharmacological properties and therapeutic indications, the main pharmacokinetic parameters, side effects, drug interactions and contraindications. Pharmacokinetics: At the end of the course, students should be able to :

• Describe the various stages in the life cycle of an active chemical ingredient (Absorption, Distribution, Metabolism and Excretion) contained in a pharmaceutical speciality, after administration to humans.
• Describe the various mechanisms involved in these stages
• Define the various pharmacokinetic parameters: bioavailability, volume of distribution, clearance, half-life times, etc.
• Calculate these parameters using non-compartmental analysis or pharmacokinetic models.

Toxicology: At the end of the course, students should be able to :

• Describe the general principle of the metabolism of a PA contained in a pharmaceutical speciality, after administration to humans.
• Describe the different modes of action of a toxic substance
• Describe the toxicology of ethanol and paracetamol
• Describe the main stages of clinical investigation (preclinical studies)

Content Pharmacology: 14h Psychotropic drugs

• Anxyolitic
• Hypnotics
• Neuroleptics
• Mood regulators
• Antidepressants

Drugs used in neurology

• Anti-epileptics

Pain and inflammation

• Peripheral analgesics
• NSAIDs, glucocorticoids
• Asthma and COPD medications

Pharmacokinetics: 10h - CM + 6h - TD I-Pharmacokinetic ADME stages: for each stage we describe

• The journey through the body
• Mechanisms involved (tissue and cell passages, biotransformations, etc.)
• Factors limiting the path of the active ingredient
• Characteristic pharmacokinetic parameters

I-a. Absorption phase (oral route only) I-b. Distribution phase I-c. Metabolism phase I-d. Excretion phase II- Pharmacokinetic analysis: II-a. Calculation of pharmacokinetic parameters by non-compartmental analysis II-b. Calculation of pharmacokinetic parameters by compartmental analysis :

• Notion of pharmacokinetic model
• Analysis after IV administration: 1-compartment model
• Analysis after IV administration: 2-compartment model
• Analysis after oral administration: 1-compartment model

Toxicology: 18h

• Describe the general principle of the metabolism of a PA contained in a pharmaceutical product, after administration to humans:

- Describe the different stages in the functionalization and conjugation of PAs - Describe the mechanisms behind variations in metabolism (age, pathology, enzymatic induction and inhibition, etc.)

• Describe the different modes of action of a toxic substance (action on DNA, lipids and proteins, depending on the different characteristics of a toxic substance), detoxification systems, etc.
• Ethanol toxicology: general information, fate in the body (ADME), mechanisms of toxic action, symptomatology
• Paracetamol toxicology: fate in the body, mechanisms of toxic action, symptomatology
• Main stages of clinical investigation: preclinical studies (Acute Toxicity Studies, Subacute Toxicity Studies, Mutagenesis Studies, Teratogenesis Studies, Local Tolerance Studies)

Speakers

• F. MACARI
• L. VIAN
• S. KHIER
• P. POUCHERET
• A. MICHEL

Objectives Through the teaching of therapeutic chemistry, students are expected to acquire a sound knowledge of the drug families covered. Therapeutic chemistry describes the classification of each drug family, covering structure, structure-activity relationships, physico-chemical properties in relation to phamacokinetic parameters, and therapeutic indications in relation to pharmacokinetics. The objectives of the "Peptide synthesis" section are :

• understand the uses of peptides in healthcare (as active ingredients and pharmacological tools) and the main techniques for producing peptide collections.
• propose a synthesis strategy and know how to implement it in a practical way, to obtain a simple peptide.
• know how to analyze a peptide and purify it using chromatography.

Contents Therapeutic chemistry 30h

• Drug nomenclature (INN and specialty name)
• Cardiovascular drugs (ß-blockers, ACE inhibitors, SARTANS, diuretics, antiangiotics, normolipidemics)
• Drugs used in neurology (anti-parkinsonian, anti-Alzheimer's)
• Pain and inflammation (anti-asthmatics, NSAIDs, glucocorticoids, anti-ulcers, analgesics, anti-histamines)
• Infectious diseases drugs (ß-lactams and anti-retrovirals)
• Oncology drugs
• Biotech drugs (immunosuppressants, insulins, etc.)

Peptide synthesis (12h CM and 8h TP)

• Peptides: general information and uses in healthcare
• Principle of synthesis on support, automation concepts
• Peptide synthesis strategies, protective groups, activating agents
• Solid-state peptide synthesis (Fmoc/tBu strategy)
• Synthesis of peptide collections: practical work on split/mix synthesis of a library of 8 tripeptides, LC/MS analysis.

Speakers

• V. LISOWSKI
• G. SUBRA
• N. MASURIER
• C. GOZE

Objectives Acquire a basic understanding of biomaterials:

• Learn about the major classes of biomaterials, their properties and main applications: polymers, metals and ceramics.
• Understand the different prerequisites for biomaterials used in implantable DM or tissue engineering matrix applications.
• Understanding the biomaterial/cell interactions that govern the tissue integration of biomaterials
• Learn about the different 3D printing methods and how to print in 3D: from computer-aided design to g-code editing and printing.
•  Know the main polymer synthesis methods
• Know the characteristic macromolecular parameters of a polymer
• Techniques for characterizing polymers
• Understanding the link between properties and applications, particularly biomedical applications

Course contentTU : Lectures (30h) Biomaterials:

•  Biomaterials in general: Metals, ceramics and bioveres
• Introduction to biomaterial/cell interactions for implantable materials
• Polymers :
• General knowledge: History of polymers and major industrial applications; Macromolecular properties versus Degradation
• Synthesis: Main polymer synthesis methods and their impact on properties
• Macromolecular parameters and characterization: Molar masses; Crystallinity; Glass transition
• Introduction to natural polymers in healthcare
• Innovative shaping techniques: Introduction to 3D printing techniques Speakers : C PINESE B NOTTELET H Van Den Berghe

Objectives: Understand the workings and missions of the pharmaceutical industry and gain an overview of the different professions available to students. Students will be able to :

• Describe the different stages in drug development
• Describe the missions of the main regulatory agencies (ANSM, EMA, FDA) and their organization/functioning
• Find a text in the main regulatory repositories (CSP, Eudralex, 21 CFR, ICH, etc.)
• Describe the principles of Good Clinical Practice and Good Manufacturing Practice
• Understand the principles of audits and inspections
• Explain how a clinical trial works, the players involved and their roles
• Describe the content of the CTD and explain how and what Module 3 is made up of

Contents:

• I- General information on the pharmaceutical industry. Drug life cycle
• II- Pharmaceutical regulatory institutions worldwide (France, Europe, USA, WHO) and main standards (CSP, Eudralex, 21CFR, ICH)
• III- Good Manufacturing Practices (GMP, GCP, concept of audits and inspections)
• IV- Clinical trials: procedures, authorizations, monitoring and management of investigational medicinal products
• V- Common Technical Document: Focus on module 3

Speakers: Montpellier University

• V. BOISSERIE LAPORTE
• Stakeholders Sanofi

Objectives Communication: Know how to express yourself, use relevant and appropriate communication techniquesPEC:Finalize the construction of your Portfolio of Experience and Skills Content Communication :

• Organizing and structuring thought ;
• Develop expression skills: narration, explanation and argumentation ;
• Boosting non-verbal communication ;
• Adapt attitudes and behavior.

PEC

• Add value to your experience and skills
• Draw up a career plan and end-of-year internship project
• Positioning yourself when faced with a job offer
• Interviewing a professional

Speakers

• B. BAÑULS
• A. PRATALI

ENGLISH

Objectives

• Strengthening English communication skills
• Speaking and oral interaction
• Reading and listening comprehension
• Written expression

Contents

• Oral presentations
• Work on written documents and videos
• Editorial work
• Learn general English and English for the workplace

Speakers Montpellier University

• I. MAITRE DEVALLON
• MR BERNET

GERMAN

Objectives

• Fluency in spoken and written French
• Independent Speaking
• Introduction to medical specialty language
• Introduction to current events in German-speaking countries

Contents

• Analysis of newspaper articles, TV programs and other authentic documents to understand various aspects of current events in Germany.
• Study of a few medical or more broadly scientific subjects

Speakers Montpellier University

• P. WEINMANN

SPANISH

Objectives

• Review basic Spanish grammar and eliminate persistent gaps and different levels. Adapt basic knowledge to the needs of each student
• Understanding audio-visual documents
• Reading comprehension and translation into French
• Specialized vocabulary acquisition
• Mastery of the Prezi presentation tool (after giving the Prezi tutorial)
• A cultural approach to working with images by the Prado painters
• Knowledge of various Spanish and Latin American companies
• Perfecting speaking skills

Contents THE TEACHER GIVES :

• Scientific news text (source El Pais - El Mundo)
• Video documents (Internet source)

THE STUDENT PRESENTS :

• Prezi creation
• Grammar exercises and lessons on a dedicated platform

Speakers Montpellier University

• Y-H. ZAMBRANO

Objectives

• Identify the right statistical methodology to suit the question and the nature of the data (choice of test, conditions of application, etc.).
• Implement the chosen methodology using a free tool
• Interpret statistical results in terms of their practical application
• Take a critical look at an existing methodology.

Content CM: 22H, TD: 16H and Project: 10h of personal work

• Reminder: parametric tests (comparison of means, variances)
• Non-parametric tests
• 1-factor analysis of variance
• Analysis of variance with 2 crossed factors
• Simple regression analysis
• Calculating the number of subjects
• Principal Component Analysis
• Hierarchical Classification

Speakers

• R. SABATIER
• C. REYNES
• M. VIVIEN

Objectives The aim of this course is to introduce students to the Galenic Pharmacy approach, which ensures the transformation of an active molecule into a safe, effective, high-quality drug, presented in a form suitable for therapeutic use. Students will learn about the main pharmaceutical raw materials used in drug formulation, as well as packaging materials. The main galenic forms will be presented, as well as the criteria leading to their selection, formulation, manufacture and packaging. Contents

• General information on the criteria for choosing a galenic form
• Raw materials used in drug formulation
• Packaging materials
• Galenic forms, their physico-chemical and administration specificities, formulation excipients, packaging and controls.

• Lectures: 34h
• Tutorial: 4h (2 sessions of 2h)
• Practical work: 12h (4 sessions of 3h)

Speakers

• MR DELALONDE
• B. BATAILLE
• T. SHARKAWI
• I. SOULAIROL

Objectives

• Prioritizing protein structural families
• Understand the theoretical and analytical arguments of normal and tumor cell signaling
• Know the main tools of genetic engineering

Contents

• Structure/function and signaling pathways of membrane proteins, nuclear receptors and adhesion molecules
• Basics of structural biochemistry
• Fundamentals of genetic engineering
• Basics of oncogenesis
• Study methods: protein identification, expression level measurement, purification; protein complex interaction analysis

• Mandatory lectures and tutorials
• 2 hands-on workshops during the day MANDATORY

Speakers

• S. MARY
• A. CHOQUET
• A-D. LAJOIX
• C. PLANQUE
• C. ROUMESTAND

Objectives To gain an overview of the different professions for which the Health and Environment Project Management course provides training.

• Health-Safety-Environment Manager
• Quality Manager
• Product stewardship (responsible for the safety and environmental impact of products)
• Expert in risk assessment (Health, Environment)
• Sustainable development
• Safety prevention
• Etc.

Contents COURSE

• Environment and health: concrete applications in the workplace
• Hygiene and chemical and biological hazards - a history of awareness
• Risk assessment principles
• Sustainable development

EXPERIENCE FEEDBACK

• Product stewardship, MSDS
• Corporate safety management by an HSE manager
• Work of the Association Régionale de l'Amélioration des Conditions de Travail (Regional Association for the Improvement of Working Conditions)

Speakers

• A. ESCANDE
• E. GOMEZ
• A. FAVRY
• M-L. TEISSEIRE (EQUITOX)
• M-H. BOUISSAC (DIRECCTE Languedoc-Roussillon)
• C. PINEL (ARACT Languedoc-Roussillon)

Objectives

• Marketing: Introduction to healthcare marketing and the strategic challenges facing the healthcare industry
• Quality management: understand the essential principles of quality management and know the steering tools and measurement systems.
• Statistical control: Master the main statistical tools used in quality control for production and method validation in analytical control.

Contents MARKETING: 9h

• The marketing approach
• The drug market: characteristics and analysis
• The strategic challenges facing healthcare manufacturers
• Sustainable development

ESSENTIAL PRINCIPLES OF QUALITY MANAGEMENT: 2h

• Definitions and related vocabulary
• Challenges and benefits
• Standards, certification and accreditation

PROCESS APPROACH: 3h

• Process representation
• Process management

IMPROVEMENT CONTINUOUS: 3h

• The principles of continuous improvement
• Internal and external audit

TD 1: the process approach: process description, analysis and management - 1h30 TD 2: continuous improvement: planning and measurement system - 1h30 STATISTICAL CONTROL :

• Introduction to statistical process control
• Introduction to statistical validation in analytical control

Speakers

• P. RAVEL
• E. ROBIN
• F. OLGIATI

ENGLISH

Objectives

• Strengthening English communication skills
• Speaking and oral interaction
• Reading and listening comprehension
• Written expression

Contents

• Oral presentations
• Work on written documents and videos
• Editorial work
• Learn general English and English for the workplace

Speakers Montpellier University

• I. MAITRE DEVALLON
• MR BERNET

GERMAN

Objectives

• Fluency in spoken and written French
• Independent Speaking
• Introduction to medical specialty language
• Introduction to current events in German-speaking countries

Contents

• Analysis of newspaper articles, TV programs and other authentic documents to understand various aspects of current events in Germany.
• Study of a few medical or more broadly scientific subjects

Speakers Montpellier University

• P. WEINMANN

SPANISH

Objectives

• Review basic Spanish grammar and eliminate persistent gaps and different levels. Adapt basic knowledge to the needs of each student
• Understanding audio-visual documents
• Reading comprehension and translation into French
• Specialized vocabulary acquisition
• Mastery of the Prezi presentation tool (after giving the Prezi tutorial)
• A cultural approach to working with images by the Prado painters
• Knowledge of various Spanish and Latin American companies
• Perfecting speaking skills

Contents THE TEACHER GIVES :

• Scientific news text (source El Pais - El Mundo)
• Video documents (Internet source)

THE STUDENT PRESENTS :

• Prezi creation
• Grammar exercises and lessons on a dedicated platform

Speakers Montpellier University

• Y-H. ZAMBRANO

Objectives

• Put students in a situation opposite their future job in industry
• Know the industrial environment, the context, the work process, the constraints, how to draw up documents

Content The 2-month internship is full-time and continuous, in a private or public sector company or research laboratory. The internship can take place in France or abroad.

Speakers: B. BAÑULS

Objectives

• Demonstration of physical phenomena at interfaces: air/liquid, liquid/liquid and liquid/solid
• Characterize these phenomena and understand the challenges of formulating dispersed systems in various industries: pharmaceuticals, cosmetics, agri-food, phytosanitary, etc. For three systems: emulsions, suspensions and foams.
• Raising awareness of the raw materials used in the formulation of cosmetic and pharmaceutical products.

Contents MAGISTRATIC COURSES: 10h

• Surfactants - Dispersed systems - Liquid interfaces - Solid interfaces
• Emulsions - Foams - Suspensions

PRACTICAL WORK: 6 sessions of 3 hours each

• S. 1: Study the phase behavior of surfactants using the ternary diagram method
• S. 2: Physico-chemical characterization of surfactant mixture preparations and determination of CMC
• S. 3: Production of a final formulation from a phase diagram - Dermo-cosmetic emulsion
• S. 4: Study the foaming and wetting power of surfactants
• S. 5: Formulating suspensions: application to toothpastes
• S. 6: Oral presentation of students' experimental results

Speakers

• A. AUBERT
• H. DABBOUE
• M. MORILLE