Bachelor degree

Bachelor degree2016-07-18T20:36:36+00:00

The degree’s programme below can also be downloaded as a pdf document.

The second year of the degree : L2 Life sciences, Health Engineering course (semesters 3 and 4)

Assessment guidelines of the Degree 2 option Life sciences, Health Engineering course / University year 2015/2016

Year taught at the Faculty of Pharmacy and at the Faculty of Sciences.

L2
The third year of the degree : L3 Life sciences, Health Engineering course (semesters 5 and 6).

Assessment guidelines of the Degree 3 option Life Sciences, Health Engineering course/University year 2015/2016

This year will allow the students to gain knowledge in physical chemistry, pharmacology, biology, pharmaceutical and bio-technological sciences which are necessary to move on to a Master that is specialised in the field of Health Engineering.

L3 SEMESTER 5

TU 1: INSTRUMENTAL TECHNIQUES FOR THE ANALYSIS OF PHARMACEUTICAL SUBSTANCES

Goals:

To train the students in the different techniques for analysing solutions as well as the solid state, which will allow them to approach through experimentation the analysis and the control of active principles alone or in pharmaceutical forms as well as pharmacokinetics.
1 – To be able to determine and characterise the crystalline using thermal and diffractoremic methods.
Quantity analysis of the different components in pharmaceutical substances/blood/urine by atomic spectrophotometry.
2 – Conceptualisation and establishment of a template of Newtonian, non-Newtonian and viscoelastic behaviours. Application to health products’ viscosimetric and rheologic mesures.
3 – Initiation to separative analytical methods and to their interaction with mass spectrometry, application to the identification and quantity analysis of xenobiotics.

Content: (Lecture-Tutorial-Practical work)

The various analysis methods are presented in lectures and illustrated by many medicine related examples. A few hours of tutorials will demonstrate the complementarity of all these techniques. Many practical work sessions (32 hours/ student) that are directly linked to the lectures will enable to students to get accustomed to the various types of devices and this way, to have a better understanding of all these techniques both fundamentally and technically.

Teachers:

Montpellier University

  • M. AUDRAN
  • C. PERRIN
  • H. VAN DEN BERGEN
  • A. EL GHZAOUI

TU 2: PHARMACOLOGY – PHARMACOKINETICS – TOXICOLOGY

Goals:

Pharmacology:
Through the pharmacology lessons, the student must have acquired a strong knowledge of the families of medications addressed in class. The pharmacology teacher describes the mechanism(s) of action of each medications family, the pharmacological properties and the therapeutic indications that result from it, the main pharmacokinetic factors, the side effects, the drug interactions and the main contraindications.
Pharmacokinetics:
At the end of the course, the student should be able to:

  • Describe the different stages of the journey of a chemical active principle (Absorption, Distribution, Metabolism and Excretion) contained in a pharmaceutical product after administration to a human being.
  • Describe the different mechanisms involved in these stages.
  • To define the different pharmacokinetic factors: Bioavailability, distribution volumes, clearances, half-times…
  • To calculate these factors using non compartmental analysis or pharmacokinetic models.

Toxicology:
At the end of the course, the student should be able to:

  • Describe the general principle of the metabolism stage of an active principle contained in a pharmaceutical product after administration to a human being.
  • Describe the different action modes of a toxic substance
  • Describe the toxicology of ethanol and paracetamol
  • Describe the main stages of clinical investigation (pre-clinical studies)

Content:

Pharmacology: 14h
Psychotropic drugs

  • Anxyolitics
  • Hypnotics
  • Neuroleptics
  • Mood regulators
  • Anti-depressants

Medication used in neurology

  • Anti-épileptics

Pain and Inflammation

  • Pheripheral analgesic
  • NSAIs, glucocorticoids
  • Medicines used for asthma and COPD

Pharmacokinetics: 10h – Lecture + 6h – Tutorial class
I-ADME Pharmacokinetic stages: for each stage the following will be described

  • The journey in the body
  • The mechanisms involved (tissue and cell passing, biotransformations…)
  • The limiting factors of the active principle’s journey
  • Typical pharmacokinetic factors

I-a. Absorption stage (orally only)
I-b. Distribution stage
I-c. Metabolism stage
I-d. Excretion stage

II- Pharmacokinetic analysis:
II-a. Calculation of the pharmacokinetic factors using non-compartmental analysis
II-b. Calculation of the pharmacokinetic factors using compartmental analysis :

  • Concept of pharmacokinetic model
  • Analysis after administration IV: 1 compartment model
  • Analysis after administration IV : 2 compartment model
  • Analysis after oral administration: 1 compartment model

Toxicology: 18h

  • To describe the general principle of the metabolism stage of an active principle contained in a pharmaceutical product after administration to a human being:

– To describe the different stages of active principles’ functionalisation and conjugation
– To describe the mechanisms underlying these metabolism variations (age, pathology, inductions and enzyme inhibitions phenomenons…)

  • Décrire les différents modes d’action d’une substance toxique (action au niveau de l’ADN des lipides, des protéines en fonction de différentes caractéristiques d’un toxique), systèmes de détoxification
  • Toxicologie de l’éthanol: généralités, devenir dans l’organisme (ADME), mécanismes d’action toxique, symptomatologie
  • Toxicologie du paracétamol : devenir dans l’organisme, mécanismes d’action toxique, symptomatologie
  • Principales étapes de l’investigation clinique : études précliniques (Etudes de Toxicité aiguë, de toxicité subaiguë, Etudes de Mutagenèse, Etudes de Tératogenèse, Etudes de Tolérance locale)

Teachers:

  • F. MACARI
  • L. VIAN
  • S. KHIER
  • P. POUCHERET
  • A. MICHEL

TU 3: THERAPEUTIC CHEMISTRY–PEPTIDE SYNTHESIS

Goals:

Through the therapeutic chemistry lessons, the student must have acquired some strong knowledge of the families of medicines addressed in the class. The therapeutic chemistry course describes the classification of each medicine family addressing the structure, the relations between structure and activity, the physico-chemical properties related to pharmacokinetic factors as well as the therapeutic indications linked to pharmacokinetic.
The goals of the « peptide synthesis » part are:

  • To understand the use of peptides in the health sector (as active principles and pharmacological tools) as well as the main techniques allowing the collection of peptides.
  • To propose a synthesis strategy and to know how to implement it in a practical way to obtain a simple peptide.
  • To know how to analyse a peptide and to purify it by chromatography.

Content:

Therapeutic chemistry 30h

  • List of medicines (DCI and speciality name)
  • Cardio-vascular system’s medicines (ß-blockers, IEC, SARTANS, diuretics, antiangoreux, normolipémiants)
  • Medicines used in neurology (anti-parkinson’s disease, anti-Alzheimer)
  • Pain and inflammation (anti-asthmatis, AINS, glucocorticoids, anti-ulcer drugs, analgesics, anti-histamines)
  • Medicines in infectology (ß-lactam and anti-retroviral)
  • Medicines in oncology
  • Medicines produced by biotechnologies (immunosuppressants, insulins …)

Peptide synthesis (12hrs of lecture and 8hrs of tutorial class)

  • Peptides, general points and uses in the health sector
  • Principle of the synthesis on medium, concepts of automation
  • The different strategies of peptide synthesis, protection groups, activation agents
  • Peptide synthesis on solid medium (Fmoc/tBu strategy)
  • Peptide collection synthesis: Practical work, split/mix synthesis of a bank of 8 tripeptides, LC/MS analysis.

Teachers:

  • V. LISOWSKI
  • G. SUBRA
  • N. MASURIER
  • C. GOZE

TU 4: THERAPEUTIC BENEFIT POLYMERS

Goals:

Acquire the basic notions in polymer synthesis and characterisation:

  • To know the main groups of polymers and their main applications
  • To know the main methods of polymer synthesis
  • To know the typical macromolecular factors of a polymer
  • To know the techniques allowing to characterise polymers

To understand the link property/applications, in particular biomedical applications

Content:

General knowledge of the polymers:

  • Polymer history and main industrial applications
  • Macromolecular properties versus degradation

Synthesis :

  • Main methods of polymer synthesis and their consequences on the properties: Polycondensation
  • Chain, radical, ionic polymerisation

Macromolecular factors and characterisation:

  • Molar masses
  • Chrystallinity
  • Glass transition
  • Introduction to polymer visco-elasticity

Teachers:

Montpellier University

  • B. NOTTELET
  • J. COUDANE

TU 5: TECHNICAL AND REGULATORY ENVIRONNEMENT OF HEALTH INDUSTRIES AND PRODUCTS

Goals:

To understand the functioning and the missions of the pharmaceutical industry and to have an overview of the different professions accessible to students.
The student will be able to :

  • Describe the different stages of a medicines development
  • Describe the missions of the main regulatory agencies (ANSM, EMA, FDA) and their organisation/functioning
  • To find a text in the main regulatory registers (CSP, Eudralex, 21 CFR, ICH, etc.)
  • To describe the principles of Good Clinical Practices and Good Manufacturing Practices
  • To understand the principles of audits and inspections
  • To explain the proceedings of a clinical trial, the participants involved and their roles
  • To describe the content of the CTD and to explain what module 3 consists of

Content:

  • I- General points on the pharmaceutical industry. Lifecycle of the medicine
  • II- Medicines’ regulatory institutions in the world (France, Europe, USA, WHO) and the main registers (CSP, Eudralex, 21CFR, ICH)
  • III- The Good Practices of… (BPF, BPC, notions of audits and inspections)
  • IV- Clinical trials : proceedings, authorisations, monitoring and management of experimental medicines
  • V- Common Technical Document : Focus on module 3

Teachers:

Montpellier University

  • B. BANULS
  • V. BOISSERIE

TU 6: COMMUNICATION TECHNIQUES – PES

Goals:

Communication : To be able to express oneself, use communication techniques in a relevant and adapted mannerPES : To finalise the construction of one’s Portfolio of Experience and Skills

Content:

Communication :

  • To organise and structure one’s thought;
  • To develop one’s ability to express oneself : narrative, explanation and argumentation ;
  • To dynamise one’s non-verbal communication;
  • To adapt one’s attitudes and behaviours.

PES

  • To enhance one’s experiences and skills
  • To develop one’s professional project and one’s end of year work placement project
  • So apply for a job
  • To interview a professional

Teachers:

  • B. BAÑULS
  • A. PRATALI

TU 7: FOREIGN LANGUAGES

ENGLISH

Goals:

  • To strengthen communication skills in English
  • Speaking and oral interactions
  • Written and oral comprehension
  • Writing

Content:

  • Oral presentations
  • Work on written documents and films
  • Written work
  • Learning general English and English adapted to the work place

Teachers:

Montpellier University

  • I. MAITRE DEVALLON
  • M. BERNET

GERMAN

Goals:

  • Knowledge and practice of everyday language, both oral and written
  • Speaking autonomously
  • Introduction to the language specific to medical field
  • Introduction to the news of German speaking countries

Content:

  • Analysis of press articles, of tv programmes or other authentic documents to undertand different aspects of German news.
  • Study of some medical or more broadly scientific topics.

Teachers:

Montpellier University

  • P. WEINMANN

SPANISH

Goals:

  • To revise Spanish grammar fundamentals and to eliminate persistent difficulties and uneven levels. To adapt the basic knowledge to each student.
  • Comprehension of audio-visual documents
  • Comprehension of the written word and translation into French
  • Learning the specialized lexicon
  • Mastering the presentation tool Prezi (after having given the Prezi tutorial)
  • Cultural approach and pictorial work by the Prado painters
  • Knowledge of various Spanish and Latin-American companies
  • Improving oral skills

Content:

THE TEACHER GIVES:

  • A text on scientific news (source El Pais – El Mundo)
  • Video documents (Source Internet)

THE STUDENT PRESENTS:

  • Prezi creation
  • Exercices and grammatical courses on dedicated platform

Teachers:

Montpellier University

  • Y-H. ZAMBRANO

L3 SEMESTER 6

TU 1: METHODS FOR THE STATISTICAL ANALYSIS OF PHARMACEUTICAL DATA

Goals:

  • To be able to identify the relevant statistical methodology according to the question and to the nature of the data (choice of the test, conditions of application…)
  • To be able to implement the chosen methodology using a free and multiplatform tool (Rcommander already used in the curriculum)
  • To be able to interpret statistical results in terms of practical application
  • To take a critical look at an existing methodology.

Content:Lecture: 22hrs, Tutorial class: 16hrs and Project: 10hrs of personal work

  • Reminder: parametric tests (comparing averages and variances)
  • Non-parametric tests
  • 1 factor variance analysis
  • 2 cross factors variance analysis
  • Simple regression analysis
  • Calculating the number of topics
  • Analysis in Main Components
  • Hierarchical classification

Teachers:

  • R. SABATIER
  • C. REYNES
  • M. VIVIEN

TU 2: GALENIC PHARMACY AND FORMULATION

Goals:
The purpose is to introduce the students to the approach of the Galenic Pharmacy which ensures the transformation of an active molecule into a quality,
safe and efficient medicine presented in a shape suitable for therapeutic usage. The students will have to know the main pharmaceutical raw materials
used in the formumation of medicines as well as the packaging materials. The main galenic forms will be presented as well as the criteria that lead to
their choice, to their formulation, to their manufacturing and packaging.

Content:

  • General points regarding the galenic form’s choice criteria
  • Raw materials included in the formulation of the medicines
  • Packaging materials
  • Galenic forms, their physicochemical and administration specificities, their formulation’s excipients, their packaging and their inspections.
  • Lectures: 34hrs
  • Tutorials: 4hrs (2 sessions of 2hrs)
  • Practical work: 12hrs (4 sessions of 3hrs)

Teachers:

  • M. DELALONDE
  • B. BATAILLE
  • T. SHARKAWI
  • I. SOULAIROL
  • F. MADANI

TU 3: CELLULAR SIGNALING AND BIO-ENGINEERING

Goals:

  • To rank protein structural families
  • To comprehend the theoretical and analytical arguments of normal and tumorous cellular signalling
  • To know the mail tools of bio-engineering

Content:

  • Structure/fonction and signaling pathways of membrane proteins, nuclear receptors and adhesion molecules
  • Basics of structural biochemistry
  • Basics of bio-engineering
  • Basics of oncogenesis
  • Methods of studies: of identification, of expression level measurement, of protein purification; analysis of protein complexes interaction
  • COMPULSORY lectures and tutorials
  • 2 COMPULSORY practical work sessions in a day

Teachers:

  • S. MARY
  • A. CHOQUET
  • A-D. LAJOIX
  • C. PLANQUE
  • C. ROUMESTAND

TU 4: ENVIRONNEMENT ENGINEERING– RADIOLOGY – NUTRITION AND HEALTH

Objectifs:
To have an overview of the different professions that the Environmental Health Project Management training leads to:

  • Health – Safety – Environment Manager
  • Quality Manager
  • Product stewardship (managing the products’ safety and their impact on the environment)
  • Risk assessment expert (Health, Environnement)
  • Sustainable development
  • Safety specialist
  • Etc.

Content:

COURSE :

  • Environmental health: concrete applications in the work place
  • Hygiene and chemical and biological risks– story of a realisation
  • The principles of risk assessment
  • Sustainable developments

EXPERIENCE FEEDBACKS :

  • Product stewardship, FDS
  • Safety management in the workplace by an HSE manager
  • Works of the Regional Association for the Improvement of Work Conditions

Teachers:

  • A. GARD
  • C. CASELLAS
  • A. FAVRY
  • M-L. TEISSEIRE (EQUITOX)
  • M-H. BOUISSAC (DIRECCTE Languedoc-Roussillon)
  • C. PINEL (ARACT Languedoc-Roussillon)

TU 5: MARKETING- QUALITY MANAGEMENT –QUALITY STATISTICAL CONTROL

Goals:

  • Marketing: Initiation to health marketing and to the strategic stakes of the health industries
  • Quality management: to understand the essential principles of quality management and to know the monitoring tools and measurement systems.
  • Statistic control: To master the main statistic tools used for production quality control and to validate analytical control methods.

Content:

MARKETING :9hrs

  • The marketing approach
  • The market of medicinal products: features and analysis
  • The strategic stakes of health industrials
  • Sustainable developments

THE ESSENTIAL PRINCIPLES OF QUALITY MANAGEMENT: 2hrs

  • Definitions and related vocabulary
  • The stakes and the benefits
  • The guidelines, certification and accreditation

THE PROCESS APPROACH: 3hrs

  • The representation of processes
  • The monitoring of processes

THE CONTINUOUS IMPROVEMENT: 3hrs

  • The principles of continuous improvement
  • The internal and external audit

Tutorial 1 : the process approach: description, analysis and process monitoring– 1hr30
Tutorial 2 : continuous improvement: planning and measurement system – 1h30

STATISTICAL CONTROL :

  • Introduction to processes statistical control
  • Introduction to statistical validation in analytical control

Teachers:

  • B. BAÑULS
  • P. RAVEL
  • N. DELELIGNE
  • F. OLGIATI

TU 6: FOREIGN LANGUAGES

ENGLISH

Goals:

  • To strengthen communication skills in English
  • Speaking and oral interaction
  • Written and oral comprehension
  • Written work

Content:

  • Oral presentations
  • Work on written documents and films
  • Writing
  • To learn general English and the language adapted to the work place.

Teachers:

Montpellier University

  • I. MAITRE DEVALLON
  • M. BERNET

GERMAN

Goals:

  • Knowledge and practice of the everyday language orally and in writing
  • Speaking autonomously
  • Introduction to the language specific to the medical field
  • Introduction to the news of German speaking countries

Content:

  • Analysis of press articles, tv programmes or other authentic documents to understand various aspects of the German news
  • Study of some medical or more broadly scientific topics

Teachers:

Montpellier University

  • P. WEINMANN

SPANISH

Goals:

  • To revise the grammatical basics of Spanish and to eliminate persisting difficulties and uneven levels. To adapt the basic knowledge to each student.
  • Comprehension of audio-visual documents
  • Comprehension of written word and translation into French
  • Learning the specialized lexicon
  • Mastering the presentation tool Prezi (after having given the Prezi tutorial)
  • Cultural approach and pictorial work by the Prado painters
  • Knowledge of various Spanish and Latin-American companies
  • Improving oral skills

Content:

THE TEACHER GIVES:

  • A text on scientific news (source El Pais – El Mundo)
  • Video documents (Source Internet)

THE STUDENT PRESENTS:

  • Prezi creation
  • Exercices and grammatical courses on dedicated platform

Teachers:

Montpellier University

  • Y-H. ZAMBRANO

TU 7: WORK PLACEMENT

Goals:

  • To gain experience with regard to the students’ future profession in the industry
  • To know the industrial environment, the context, the work approach, the confines, documents writing

Content:

The two-month work placement is carried out full-time within a company from the private or public sector in a research laboratory. This work placement can be done in France or abroad.

Teachers:

  • B. BAÑULS

TU 8: SURFACe PHENOMENA

Goals:

  • Demonstration of the physical phenomena present in interfaces: air/liquid, liquid/liquid, and liquid/solid.
  • Characterisation of these phenomena and understanding the challenges of the formulation of dispersed systems in various industries; pharmacy, cosmetics, food phytosanitary industry … For three systems: emulsions, suspensions and foams.
  • Awareness of the raw materials included in the formulation of cosmetic and pharmaceutical products.

Content:

LECTURES: 10hrs

  • Surface-active agents – Dispersed systems – Liquid interfaces –Solid interfaces
  • Emulsions – Foams – Suspensions

TUTORIALS: 6 sessions of 3hrs

  • S. 1 : Study of the phase behaviours of surfactants using the ternary diagram method.
  • S. 2 : Physicochemical characterisation of preparations of surfactants mix and dertermination of CMC
  • S. 3 : Carrying out a final formulation starting from a phase diagram – Dermo-cosmetic emulsion
  • S. 4 : Study of the foaming and wetting power of sufactants
  • S. 5 : Suspensions formulation: application to toothpastes
  • S. 6 : Oral presentation of the students’ experimental results

Teachers:

  • A. AUBERT
  • H. DABBOUE
  • M. MORILLE